A Novel SNP Associated with Nighttime Pulse Pressure in Young-Onset Hypertension Patients Could Be a Genetic Prognostic Factor for Cardiovascular Events in a General Cohort in Taiwan

BackgroundPulse pressure (PP) is a risk factor for cardiovascular disease. It has been reported that ambulatory blood pressure (BP) and nighttime BP parameters are heritable traits. However, the genetic association of pulse pressure and its clinical impact remain undetermined.Method and ResultsWe conducted a genome-wide association study of PP using ambulatory BP monitoring in young-onset hypertensive patients and found a significant association between nighttime PP and SNP rs897876 (p = 0.009) at chromosome 2p14, which contains the predicted gene FLJ16124. Young-onset hypertension patients carrying TT genotypes at rs897876 had higher nighttime PP than those with CT and CC genotypes (TT, 41.6±7.3 mm Hg; CT, 39.1±6.0 mm Hg; CC, 38.9±6.3 mm Hg; pConclusionThe TT genotype of rs897876C at 2p14 identified in young-onset hypertensive had higher nighttime PP and could be a genetic prognostic factor of cardiovascular events in the general cohort in Taiwan.

背景：脉压（pulse pressure, PP）是心血管疾病的危险因素。已有研究证实，动态血压（ambulatory blood pressure, BP）及夜间血压参数属于可遗传性状。然而，脉压的遗传关联及其临床影响仍未明确。
方法与结果：本研究针对早发性高血压患者的动态血压监测数据开展脉压全基因组关联研究，发现2号染色体短臂14区（2p14）的单核苷酸多态性（Single Nucleotide Polymorphism, SNP）rs897876与夜间脉压存在显著关联（p = 0.009），该区域包含预测基因FLJ16124。携带rs897876位点TT基因型的早发性高血压患者，其夜间脉压高于CT及CC基因型携带者（TT, 41.6±7.3 mm Hg; CT, 39.1±6.0 mm Hg; CC, 38.9±6.3 mm Hg; p）。
结论：本研究在早发性高血压患者中鉴定出的2p14区域rs897876位点TT基因型携带者具有更高的夜间脉压，该基因型或可作为台湾普通人群心血管事件的遗传预后标志物。