An aging-like phenotype occurs in Tif1γ-/- hematopoietic stem cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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To determine whether an accelerated aging-like phenotype occurs in hematopoiesis of young Tif1γ-/- mice (4 months old), we purified 200,000 hematopoietic stem cells (LSK: Lineage negative, Sca1+, c-Kit+) from Tif1γ-/- mice and performed high-throughput mRNA sequencing (RNA-seq). We compared this transcriptome to physiological aging by creating two other RNAseq libraries from young (4 months old) and old (20 months old) wild type mice.
为明确4月龄年轻Tif1γ基因敲除（Tif1γ-/-）小鼠的造血过程是否出现类加速衰老表型，我们从该类小鼠体内纯化获得200,000个造血干细胞（LSK：Lineage negative, Sca1+, c-Kit+），并开展高通量mRNA测序（RNA-seq）。此外，我们分别从4月龄年轻与20月龄老年野生型小鼠中构建两个RNA测序文库，将所得转录组与生理衰老的转录组进行对比分析。
提供机构：
Inserm U866
创建时间：
2022-02-20
