Association of resistome abundance with hyperuricaemia in elderly individuals: A metagenomics study

The study aimed to explore the gut resistome in elderly individuals with hyperuricemia (HUA) and its correlations with demographics, gut microbiota, and mobile genetic elements (MGEs). By enrolling 504 participants from a large community in Shenzhen, China, it was discovered that there was a heightened presence of antimicrobial resistance genes (ARGs) in the gut of those with HUA than in those without. The study highlighted associations between specific bacterial genera, ARGs, and uric acid levels, offering new insights into the intricate interplay between gut microbiota and antimicrobial resistance in the context of chronic conditions like HUA. These findings underscore the importance of considering the gut resistome in the elderly, especially those with HUA, and suggest potential avenues for interventions to mitigate antimicrobial resistance risks.

本研究旨在探讨高尿酸血症（hyperuricemia, HUA）老年群体的肠道耐药组（gut resistome），及其与人口学特征、肠道菌群和可移动遗传元件（mobile genetic elements, MGEs）的关联。本研究招募中国深圳某大型社区的504名受试者，结果显示高尿酸血症人群肠道内的抗菌药物耐药基因（antimicrobial resistance genes, ARGs）丰度显著高于非高尿酸血症人群。研究揭示了特定细菌属、抗菌药物耐药基因与血尿酸水平之间的关联，为理解高尿酸血症等慢性疾病背景下肠道菌群与抗菌药物耐药性之间的复杂互作关系提供了全新视角。上述研究结果凸显了关注老年人群肠道耐药组的重要性，尤其是高尿酸血症老年群体，并为降低抗菌药物耐药风险的干预工作提供了潜在方向。