Organocatalytic Ring-Opening Polymerization by Fluorinated Alcohol: Fulfilling Cocatalyst-Free, Metal-Free, High-Rate and High-Selectivity

we describe a fluorinated alcohol based catalytic system for polypeptide synthesis via catalytic ring-opening polymerization (ROP) of <i>α</i>-amino acid <i>N</i>-carboxyanhydride (NCA), fulfilling cocatalyst-free, metal-free, high-rate and high-selectivity. The new finding not only represents a new catalysis mode of fluorinated alcohol but also provides a metal-free and fast approach to access well-defined polypeptides, mimics of natural analogs with extensive applications.本研究报道了一种基于氟化醇的催化体系，可用于通过α-氨基酸-N-羧酸酐（NCA）的催化开环聚合（ROP）合成多肽，该体系无需助催化剂、无金属参与，且兼具高反应速率与高选择性。此项新发现不仅拓展了氟化醇的催化模式范畴，同时也为制备结构明确的多肽提供了一种无金属且快速的方法——这类多肽作为天然类似物，拥有广阔的应用前景。