Helminth-derived metabolites induce tolerogenic transcriptional and metabolic signatures in dendritic cells in experimental intestinal inflammation

The high incidence of Inflammatory Bowel Diseases (IBD) in Western societies is inversely correlated with the low incidence of intestinal helminth parasite infections, due considering the ability of helminth parasites to induce tolerance in the host. This is in part by the induction of tolerogenic dendritic cells (tolDCs). This study evaluates the role of Heligmosomoides polygyrus bakeri excretory secretory products, more specifically, metabolites, and their capacity to induce tolDCs. This study could represent a future helminth-based therapy for inflammatory diseases.

西方社会中炎症性肠病（Inflammatory Bowel Diseases, IBD）的高发病率与肠道蠕虫寄生虫感染的低发病率呈负相关，这一关联的成因在于蠕虫寄生虫能够诱导宿主产生免疫耐受。该免疫耐受的诱导过程，部分是通过耐受性树突状细胞（tolerogenic dendritic cells, tolDCs）的激活实现的。本研究对多形螺旋线虫巴克亚种（Heligmosomoides polygyrus bakeri）排泄分泌产物——尤其是其中的代谢物——的作用，及其诱导耐受性树突状细胞的能力进行了评估。本研究有望为炎症性疾病开发基于蠕虫的治疗手段提供新的研究思路。