Additional file 3 of Too much or too little opioids to patients receiving opioid agonist therapy in Norway (2013–2017): a prospective cohort study

Additional file 3. Defined daily doses (DDD) of OAT opioids and opioid analgesics converted to milligrams and morphine equivalents. DDD: Defined daily doses; OMEQ: oral morphine equivalents. The table displays the conversion of defined daily doses (DDD) to milligrams according to the WHOs’ standards (1) and the calculations of opioid analgesics to morphine equivalents (2). Only opioid analgesics that had marketing authorizations in Norway in the study period were included. (1) Definition and general considerations. In: https://www.whocc.no/ddd/ definition_and_general_considera/#Definition . WHO Collaborating Centre for Drug Statistics; 2019.(2) Svendsen K, Borchgrevink P, Fredheim O, Hamunen K, Mellbye A, Dale O: Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses. Palliat Med 2011, 25(7):725–732.

附加文件3。本文件包含阿片类激动剂治疗（OAT）相关阿片类药物与阿片类镇痛剂的毫克单位换算及吗啡等效剂量换算内容。其中，限定日剂量（Defined Daily Doses, DDD）为世界卫生组织定义的标准限定日剂量；口服吗啡等效剂量（Oral Morphine Equivalents, OMEQ）为口服吗啡等效剂量。本表格依据世界卫生组织药物统计合作中心2019年发布的规范（1），展示了限定日剂量（DDD）向毫克单位的换算方法，同时给出了阿片类镇痛剂换算为吗啡等效剂量的计算逻辑（2）。本研究仅纳入研究周期内于挪威获批上市的阿片类镇痛剂。(1) 定义与通用注意事项。详见：https://www.whocc.no/ddd/definition_and_general_considera/#Definition . 世界卫生组织药物统计合作中心；2019年。(2) Svendsen K, Borchgrevink P, Fredheim O, Hamunen K, Mellbye A, Dale O：计量单位的选择至关重要：阿片类消耗量研究中口服吗啡等效剂量的应用可作为限定日剂量的有益补充。《姑息医学》（Palliat Med）2011, 25(7):725–732.