Differentially expressed neuropeptide and neurotransmitter genes in microarray of brain.

Transcriptional responses of Acads−/− mice fed HF diet were similar to those of Acads+/+ mice fed LF diet. Fold change indicates positive (increased) or negative (decreased) expression, relative to the first strain of the comparison. Genes were selected based on a significance level of P<0.05 and ≥1.6-fold change in expression, i.e., ratio of the normalized signal intensity.喂食高脂饮食（HF diet）的Acads基因敲除小鼠（Acads−/− mice）的转录应答，与喂食低脂饮食（LF diet）的Acads+/+小鼠的转录应答相似。折叠变化（fold change）用于表征相较于比较组首个品系的基因表达上调（正值）或下调（负值）情况。基因筛选标准为显著性水平P<0.05，且表达变化倍数≥1.6倍，即归一化信号强度的比值。