Motor deficit score (MDS) and post-MDS motor neuron cell numbers in rats with spinal cord ischemia-reperfusion (IR) injury, grouped according to Simvastatin treatment

This dataset consists of two Excel spreadsheets containing:<br>1. <b>MDS (raw).xlsx</b>: Motor deficit score (MDS) data per experiment group at various time points2. <b>number of normal motor neuron.xlsx: </b>counts of normal motor neurons within the anterior horns of the spinal cord following final MDS evaluation per experiment groupNeurological function was evaluated with hind limbs motor function after reperfusion for 7 days. The observer was blinded to the group assignments. Groups were assigned based on MDS at 8 hours, 1, 3, 5 and 7 days after reperfusion (see more detailed description below. Article abstract:Background: Spinal cord ischemic injury remains a serious complication of open surgical and endovascular aortic procedures. Simvastatin has been reported to be associated with neuroprotective effect after spinal cord ischemia-reperfusion (IR) injury.The aim of the study associated with this data was to determine the therapeutic efficacy of starting simvastatin after spinal cord IR injury in a rat model.Methods: In adult Sprague-Dawley rats, spinal cord ischemia was induced using a balloon-tipped catheter placed in the descending thoracic aorta. The animals were then randomly divided into 4 groups: group A (control); group B (0.5 mg/kg simvastatin); group C (1 mg/kg simvastatin); and group D (10 mg/kg simvastatin). Simvastatin was administered orally upon reperfusion for 5 days. Neurological function of the hind limbs was evaluated for 7 days after reperfusion and recorded using a motor deficit score (MDS) (0: normal, 5: complete paraplegia). The number of normal motor neurons within the anterior horns of the spinal cord was counted after final MDS evaluation. Then, the spinal cord was harvested for histopathological examination.

本数据集包含两份Excel电子表格，具体如下：<br>1. <b>MDS (raw).xlsx</b>：各实验组不同时间点的运动功能缺损评分(Motor deficit score, MDS)原始数据；2. <b>number of normal motor neuron.xlsx</b>：各实验组完成最终运动功能缺损评分后，脊髓前角内正常运动神经元的计数结果。<br>研究于再灌注7天后评估后肢神经功能，评估者采用盲法对分组情况不知情。分组依据为再灌注后8小时、1天、3天、5天及7天的运动功能缺损评分（详细说明见下文）。<br>文章摘要：<br>背景：脊髓缺血性损伤仍是开放式手术与血管内主动脉手术的严重并发症。已有研究证实辛伐他汀对脊髓缺血再灌注(ischemia-reperfusion, IR)损伤具有神经保护作用。本数据集对应的研究旨在探究大鼠脊髓缺血再灌注损伤模型中，再灌注后启动辛伐他汀给药的治疗效果。<br>方法：选用成年斯普拉格-道利(Sprague-Dawley)大鼠，通过向胸降主动脉置入球囊导管诱导脊髓缺血造模。随后将动物随机分为4组：A组（空白对照组）；B组（0.5 mg/kg辛伐他汀组）；C组（1 mg/kg辛伐他汀组）；D组（10 mg/kg辛伐他汀组）。于再灌注即刻开始口服给药，连续5天。于再灌注后7天评估后肢神经功能，采用运动功能缺损评分(MDS)进行记录（0分表示运动功能正常，5分表示完全截瘫）。完成最终MDS评分后，计数脊髓前角内正常运动神经元的数量，随后收取脊髓组织进行组织病理学检查。