Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2

Dried blood spot (DBS) samples were collected during spring of 2020 from random and undiagnosed individuals in Stockholm, Sweden. Receiving DBS from 878 participants, we applied multiplexed serology assays to determine IgG and IgM levels against several versions of SARS-CoV-2 proteins (S, RBD, N). The data reports anonymised an normalised "relative antibody titers" obtained in the eluates of the DBS samples. The data can be made available for validation purposes and upon reasonable request. A reasonable request should contain:1) Name of PI and host organisation2) Contact details3) Scientific purpose of data access request4) Commitment to inform when the data has been used in a publication5) Commitment not to host or share the data outside the requesting organisation6) Statement of non-commercial use of data

2020年春季，研究团队从瑞典斯德哥尔摩的随机未确诊个体中采集干血斑（Dried blood spot, DBS）样本，最终获得878名参与者的干血斑样本。研究采用多重血清学检测方法，测定了针对多种严重急性呼吸综合征冠状病毒2（SARS-CoV-2）蛋白（刺突蛋白S、受体结合域RBD、核衣壳蛋白N）的IgG与IgM水平。本数据集报告了经匿名化与标准化处理的干血斑洗脱液中得到的“相对抗体滴度”。该数据集可出于验证目的，在提交合理申请后开放获取。合理申请需包含以下内容：1）项目负责人（Principal Investigator, PI）及其所属机构名称；2）联系方式；3）数据访问申请的科学用途说明；4）承诺在数据用于学术发表时向数据提供方告知相关情况；5）承诺不在申请机构以外的场所托管或共享该数据集；6）声明将非商业性使用该数据集。