Additional file 6 of Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections

Additional file 6: Supplementary File 4. Alu editing index (AEI) values from the RNA Editing Indexer method (Roth et al., 2019) for (A) the PRJEB38849 MCMV dataset, (B) the ZIKV PRJNA487357 dataset, (C) the ZIKV PRJNA358758 dataset, and (D) the hiNPC ZIKV PRJNA551246 dataset. This includes quantifications of the ratio of A-to-G mismatches to total A reads (effectively the percent of As edited to Gs) in Alu repeat elements in humans or SINE B1/B2 repeat elements in mice, as well as the same metric for other variant types. A-to-G editing index serves as a general metric of transcriptome-wide levels of hyperediting, which primarily occur in repeat regions. Quantification of other variants serve as a measure of background noise, with the next most common modification type being C-to-T editing.附加文件6：补充文件4。基于RNA编辑索引工具（RNA Editing Indexer，Roth等，2019）得到的Alu编辑指数（Alu Editing Index, AEI）数值，对应以下数据集：(A) PRJEB38849小鼠巨细胞病毒（MCMV）数据集、(B) 寨卡病毒（ZIKV）PRJNA487357数据集、(C) ZIKV PRJNA358758数据集，以及(D) 人诱导神经前体细胞（hiNPC）ZIKV PRJNA551246数据集。本文件包含人类Alu重复元件或小鼠短散在核元件（Short Interspersed Nuclear Elements, SINE）B1/B2重复元件中，A-to-G错配与总A读段的比值（即实际发生A到G编辑的A碱基占比）的定量结果，同时也涵盖其他变异类型的同类指标。A-to-G编辑指数可作为全转录组超编辑水平的通用量化指标，此类超编辑主要发生在重复区域内。其他变异类型的定量结果可作为背景噪声的衡量标准，第二常见的修饰类型为C-to-T编辑。