Bacteroides pyogenes strain:SJ36 Genome sequencing

Bacteroides species are frequently linked to uterine diseases in dairy cows, particularly metritis a postpartum uterine infection characterized by microbial dysbiosis, fever, and foul-smelling uterine discharge. Metritis can progress to endometritis and infertility later in the postpartum period. This condition is associated with disruption of the uterine microbiome, marked by the proliferation of Gram-negative anaerobes such as Fusobacterium necrophorum, Bacteroides pyogenes, and Porphyromonas levii. Despite their frequent co-occurrence, the mechanisms enabling these opportunistic pathogens to proliferate together and contribute to disease remain poorly understood. In this study, we examined the interactions among these uterine pathogens with respect to bacterial growth, survival, and virulence.

拟杆菌属（Bacteroides）物种常与奶牛的子宫疾病密切相关，尤其是产后子宫炎（metritis）——这是一种以微生物群失调、发热及子宫恶臭分泌物为特征的产后子宫感染。产后子宫炎可在产后后期进展为子宫内膜炎与不孕症。该病症与子宫微生物组（uterine microbiome）的紊乱存在关联，其典型特征为革兰氏阴性厌氧菌（Gram-negative anaerobes）的过度增殖，例如坏死梭杆菌（Fusobacterium necrophorum）、化脓拟杆菌（Bacteroides pyogenes）以及莱维卟啉单胞菌（Porphyromonas levii）。尽管这些致病菌常共同存在，但它们得以协同增殖并促成疾病发生的机制仍尚未明确。本研究围绕细菌生长、存活与毒力三个维度，探究了上述子宫致病菌之间的相互作用。