Data for Olfactory Function of Chinese PD Patients: an Event Related fMRI Study

Hyposmia is one of the early signs in idiopathic Parkinson’s disease (PD). Olfactory stimuli were applied during fMRI scanning to show disease-related modulation of central nervous system structures and to advance our understanding of olfactory dysfunction in PD patients. Although there are a few fMRI studies on hyposmia, the findings are inclusive. Therefore, Using a block design of at a 3.0 T scanner we investigated a total of 19 PD patients and 20 age matched controls, while passively perceiving a positively valenced (rose-like or lavender) odoran .Th edifferent activated brain region are also observed.

嗅觉减退（Hyposmia）是特发性帕金森病（Idiopathic Parkinson’s Disease, PD）的早期征兆之一。本研究在功能磁共振成像（fMRI）扫描过程中施加嗅觉刺激，旨在揭示疾病相关的中枢神经系统结构调控机制，并加深对帕金森病患者嗅觉功能障碍的认识。尽管已有少量针对嗅觉减退的功能磁共振成像研究，但相关研究结果尚未达成共识。因此，本研究采用3.0T扫描仪的区组设计范式，对19名帕金森病患者与20名年龄匹配的健康对照者进行扫描，受试者在此过程中被动感知玫瑰样或薰衣草样的正性气味剂，同时观察到了不同的脑区激活情况。