Dataset related to article: "Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results

This record contains data related to article "Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results"

Postural orthostatic tachycardia syndrome (POTS) is a multifactorial condition capable of
chronically reducing the quality of life and the work ability of patients. The study aim was to assess
the burden of autonomic symptoms in a cohort of POTS patients over 2 years. Patients’ clinical profiles
were assessed by the 31-item Composite Autonomic Symptom Score questionnaire (COMPASS 31)
and a visual analog scale (VAS). One-way ANOVA for repeated measures followed by Dunnett’s
post-hoc test were used to compare symptoms at baseline and at 1 and 2 years. Out of 42 enrolled
patients, 25 had a 1-year follow-up and 12 had a 2-year follow-up. At baseline, the reported burden
of autonomic symptoms was high (overall COMPASS 31 = 49.9 14.3 /100). Main complaints were
related to orthostatic intolerance according to both COMPASS 31 and VAS. Fourteen patients were
rendered inactive because of symptoms. At 1-year follow-up, a statistically significant improvement
in pupillomotor function and overall score was detected by the COMPASS 31. These findings were
confirmed at 2 years, together with a significant reduction in quality of life impairment, assessed
by VAS. However, these improvements did not change patients’ occupational status. Awareness of
POTS diagnosis, patient monitoring, and tailored therapies can help to improve patients’ condition.

本数据集包含与论文《体位性直立性心动过速综合征（Postural Orthostatic Tachycardia Syndrome, POTS）患者自主神经症状的时间进程：两年随访结果》相关的数据。

体位性直立性心动过速综合征（POTS）是一种多因素致病的疾病，可长期降低患者的生活质量与工作能力。本研究旨在评估一组POTS患者在两年随访周期内的自主神经症状负担。研究采用31项复合自主神经症状评分问卷（Composite Autonomic Symptom Score Questionnaire, COMPASS 31）与视觉模拟评分法（Visual Analog Scale, VAS）对患者的临床特征进行评估，并采用重复测量单因素方差分析（One-way ANOVA）结合Dunnett事后检验，对比基线、1年随访及2年随访时的症状水平。入组的42例患者中，25例完成了1年随访，12例完成了2年随访。基线时，患者的自主神经症状负担较高（COMPASS 31总分为49.9±14.3/100）。根据COMPASS 31与VAS评估结果，患者的主要主诉与直立不耐受相关。14例患者因该症状丧失劳动能力。1年随访时，COMPASS 31评估显示患者的瞳孔运动功能与总分均出现具有统计学意义的改善。该结果在2年随访时得到验证，同时VAS评估显示患者的生活质量受损程度显著降低。但上述改善并未改变患者的职业状态。提高POTS诊断认知、加强患者监测并实施个体化治疗，有助于改善患者的健康状况。