WP4495 - IL10 anti-inflammatory signaling - Homo sapiens

IL-10 binds to its respective IL-10 receptor which activates the JAK/STAT pathway and MAPK pathway involving the p38 kinases. This leads to the induction of the enzyme heme oxygenase-1 (HMOX1) which is involved in the biosynthesis of heme, and catalyzes the reaction producing the heme precursor biliverdin. The ani-inflammatory actions of HMOX appear to be the result of signaling by carbon monoxide which inhibits pro-inflammatory cytokine production.

白细胞介素10（IL-10）与其特异性IL-10受体结合，可激活JAK/STAT通路以及涉及p38激酶的MAPK通路。该过程会诱导血红素氧合酶-1（HMOX1）的表达，该酶参与血红素的生物合成，并催化生成血红素前体胆绿素的反应。血红素氧合酶（HMOX）的抗炎作用似乎源于一氧化碳的信号传导，后者可抑制促炎细胞因子的产生。