Erratum: Abnormal Epigenetic Modifications in Peripheral T Cells from Patients with Abdominal Aortic Aneurysm Are Correlated with Disease Development

Background: Increasing evidence suggests that abdominal aortic aneurysm (AAA) is a T-cell-mediated autoimmune condition. This study investigates the epigenetic modifications that occur in the T cells of AAA patients and evaluates the correlation of these modifications with disease development. Methods and Results: Peripheral T cells were collected from 101 AAA patients and 102 healthy controls (HCs). DNA methylation and histone acetylation levels were measured by ELISA. Methyl-CpG-binding domain, DNA methyltransferase (DNMT) and histone deacetylase (HDAC) mRNA levels were determined by real-time PCR. DNA from the T cells of the AAA patients exhibited significant hypomethylation compared with the HCs (1.6-fold, p Conclusions: DNA methylation and the histone modification status are significantly altered in the T cells of AAA patients. These changes could play a pivotal role in the activation of pathological immune responses and may influence AAA development.背景：越来越多的证据表明，腹主动脉瘤（abdominal aortic aneurysm, AAA）是一种由T细胞介导的自身免疫性疾病。本研究旨在探究AAA患者T细胞中发生的表观遗传修饰，并评估此类修饰与疾病进展的相关性。 方法与结果：本研究从101例AAA患者与102例健康对照（healthy controls, HCs）体内采集外周血T细胞。采用酶联免疫吸附试验（enzyme-linked immunosorbent assay, ELISA）检测DNA甲基化与组蛋白乙酰化水平；通过实时PCR检测甲基-CpG结合域（Methyl-CpG-binding domain）、DNA甲基转移酶（DNA methyltransferase, DNMT）以及组蛋白去乙酰化酶（histone deacetylase, HDAC）的mRNA表达水平。与健康对照相比，AAA患者T细胞的DNA呈现显著的低甲基化状态（1.6倍，p 结论：AAA患者T细胞中的DNA甲基化与组蛋白修饰状态均发生显著改变。此类改变可能在病理性免疫应答的激活过程中发挥关键作用，并可对AAA的发展产生影响。