Sensitivity to Selection Criteria Study Results Part IV: SSDQA Comparison

- For most sites, the overall characterization of the cohort did not change drastically between the two definitions. - For Nationwide, the updated attrition criteria significantly improved cohort makeup in several key areas: hematology specialty & inpatient utilization, ANC & MCV lab population, hydroxyurea exposures, and demographic distributions.

对于多数研究中心而言，两种定义下的队列整体特征均未发生显著变化。——针对全国范围的队列，更新后的队列筛选标准在多个关键领域显著优化了队列构成：涵盖血液学专科诊疗与住院利用情况、中性粒细胞绝对计数（Absolute Neutrophil Count, ANC）与平均红细胞体积（Mean Corpuscular Volume, MCV）的实验室人群特征、羟基脲暴露情况，以及人口统计学分布。