Metagenomic sequencing of T2D patients

Human gut microbiota have been proved to associate with multiple human chronic disease. The gut microbiota has been found associated with pre-diabetes and type 2 diabetes, however the association between gut microbiota and the development of cardiovascular disease in T2D patients is not clear. By comparing the metagenomes of healthy, T2D and T2D-CVD patients, we found the enrichment of K. pneumoniae strains were associated with T2D-CVD patients by producing TMA and virulence factors.

已有研究证实，人体肠道菌群（gut microbiota）与多种人类慢性疾病存在关联。现有研究发现肠道菌群与前驱糖尿病（pre-diabetes）及2型糖尿病（type 2 diabetes，简称T2D）密切相关，但肠道菌群与2型糖尿病患者群体中心血管疾病发生发展的关联仍不明确。本研究通过对比健康人群、2型糖尿病患者以及2型糖尿病合并心血管疾病（T2D-CVD）患者的宏基因组（metagenome），发现肺炎克雷伯菌（K. pneumoniae）菌株的富集与T2D-CVD患者群体存在关联，其机制为该菌株可产生三甲胺（TMA）与毒力因子。