Results of a randomised trial assessing the effectiveness of different dosages of levofloxacin to cure Helicobacter pylori infection

This dataset presents the results of a randomised clinical trial involving 400 participants, which aimed to compare the effectiveness, safety, and compliance of different dosages of levofloxacin used to cure Helicobacter pylori (H. pylori) infection. Patients were assigned to either Group A or Group B, and received esomeprazole, amoxicillin, colloidal bismuth pectin and levofloxacin 500 mg once per day (group A); or levofloxacin 200 mg twice per day (group B) over a 14 day period. The presence of H. pylori was assessed before and after the trial using c-urea breath testing (C-UBT). The dataset is comprised of an Excel spreadsheet with a single tab. Each of the 400 patients is assigned a number, and the dataset includes their baseline C-UBT result, randomised treatment group and follow-up C-UBT; any adverse reactions noted by patients during the trial period; and whether the study was completed per the protocol analysis.

本数据集呈现了一项纳入400名受试者的随机临床试验结果，该试验旨在对比不同剂量左氧氟沙星用于根除幽门螺杆菌（Helicobacter pylori，H. pylori）感染的有效性、安全性与治疗依从性。受试者被随机分配至A组或B组，两组均接受为期14天的治疗方案：A组予埃索美拉唑、阿莫西林、胶体果胶铋联合每日1次、每次500mg左氧氟沙星；B组予每日2次、每次200mg左氧氟沙星。试验前后均采用碳-尿素呼气试验（C-urea breath testing，C-UBT）评估受试者的幽门螺杆菌感染状态。本数据集以包含单个工作表的Excel电子表格形式存储，400名受试者均被赋予唯一编号，数据集包含每名受试者的基线碳-尿素呼气试验结果、随机分配的治疗组别、随访碳-尿素呼气试验结果、试验期间受试者报告的所有不良反应，以及是否按研究方案完成试验的相关信息。