RNA-Seq of MC38 tumors in CC075 x C57BL/6J mice given combinations of blocking antibodies to PD1, IL2RB, and GM-CSF.

In this study we investigated variation in responsiveness to anti-PD-1 using a model where we implanted the MC38 colorectal cancer cell line in genetically diverse host mice. This data set includes RNA-Seq samples from an experiment where we tested the effect of blocking antibodies to GM-CSF and IL2RB.本研究采用将MC38结直肠癌细胞系植入遗传多样性宿主小鼠的模型，探究了机体对抗PD-1（anti-PD-1）治疗的应答差异。本数据集涵盖一项实验的RNA测序（RNA-Seq）样本，该实验旨在评估抗粒细胞-巨噬细胞集落刺激因子（GM-CSF）与抗白细胞介素2受体β链（IL2RB）阻断性抗体的干预效果。