Association between XPD Lys751Gln polymorphism and esophageal cancer susceptibility in China: a meta-analysis based on 12 case-control studies

Abstract Many studies have analyzed the relation about xeroderma pigmentosum group D (XPD) Lys751Gln polymorphism on esophageal cancer risk; however, the results were inconclusive. The present study was designed to assess the relationship in China. We searched the relevant articles from the databases of PubMed, Springer Link, Ovid, Chinese Wanfang Database, CNKI and Chinese Biology Medicine up to December 2019. An OR with the corresponding 95%CI was adopted to evaluate this association. This meta-analysis included 12 studies with 4195 esophageal cancer cases and 4762 controls. Overall, a positive association between XPD Lys751Gln and esophageal cancer risk was found in all the analysis model (Gln vs. Lys, OR= 1.26, 95% CI= 1.14-1.44; Gln/Gln vs. Lys/Lys, OR= 1.73, 95% CI= 1.29-2.31; Gln/Gln vs. Lys/Lys + Asp/Asn, OR= 1.63, 95% CI= 1.22-2.18; Gln/Gln+ Asp/Asn vs. Lys/Lys, OR= 1.25, 95% CI= 1.13-1.39). Subgroup analyses by geographic area and source of controls were further conducted; there was no substantial change in subgroup analyses. Our study suggested that XPD Lys751Gln polymorphism could increase the risk of esophageal cancer in China. Further studies in other ethnic populations are wanted to confirm these conclusions.

摘要：已有多项研究探讨着色性干皮病D组（xeroderma pigmentosum group D, XPD）Lys751Gln多态性与食管癌发病风险的关联，但所得结论尚未达成统一。本研究旨在针对中国人群评估该多态性与食管癌发病风险的关联。我们检索了PubMed、Springer Link、Ovid、中国万方数据库、中国知网（China National Knowledge Infrastructure, CNKI）以及中国生物医学文献数据库（Chinese Biology Medicine）截至2019年12月的相关文献。本研究采用比值比（odds ratio, OR）及其对应的95%置信区间（95% confidence interval, 95%CI）来评价二者的关联强度。本次荟萃分析（meta-analysis）共纳入12项相关研究，涉及4195例食管癌患者及4762例对照个体。总体而言，在所有分析模型中均观察到XPD Lys751Gln多态性与食管癌发病风险存在正相关：Gln vs. Lys（OR=1.26，95%CI=1.14~1.44）；Gln/Gln vs. Lys/Lys（OR=1.73，95%CI=1.29~2.31）；Gln/Gln vs. Lys/Lys + Asp/Asn（OR=1.63，95%CI=1.22~2.18）；Gln/Gln+Asp/Asn vs. Lys/Lys（OR=1.25，95%CI=1.13~1.39）。进一步按地理区域及对照来源进行亚组分析，亚组分析结果未出现显著改变。本研究结果显示，在中国人群中，XPD Lys751Gln多态性可升高食管癌的发病风险。后续需在其他种族人群中开展相关研究以验证本研究结论。