Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity

We provide a map of human ILC heterogeneity across multiple anatomical sites. Tissue-specific distinctions are particularly apparent for ILC1 populations, whose distribution was markedly altered in obesity or aging. Furthermore, the degree of ILC1 population hetero- geneity differed substantially in lymphoid versus mucosal sites. Together, these analyses comprise a comprehensive characterization of the spatial and temporal dynamics regulating the anatomical distri- bution, subset heterogeneity, and functional poten- tial of ILCs in non-diseased human tissues. We present a quantitative analysis of ILC distribution and heterogeneity in lymphoid, mucosal, and metabolic tissues obtained from a diverse cohort of 44 previously non-diseased organ donors over a wide range of ages and body mass indexes (BMIs).

本研究构建了多解剖部位的人固有淋巴细胞（Innate Lymphoid Cells, ILC）异质性图谱。组织特异性差异在ILC1亚群中尤为显著，该亚群的分布在肥胖或衰老状态下会发生显著改变。此外，ILC1亚群的异质性程度在淋巴组织与黏膜组织间存在显著差异。综上，本研究通过上述分析全面表征了非病变人类组织中ILC的解剖分布、亚群异质性与功能潜能的时空调控特征。本研究针对44名既往无疾病史、涵盖广泛年龄范围与身体质量指数（Body Mass Index, BMI）区间的器官供体队列的淋巴组织、黏膜组织及代谢组织中的ILC分布与异质性开展了定量分析。