Fh1

Enables fumarate hydratase activity. Involved in several processes, including fumarate metabolic process; positive regulation of cold-induced thermogenesis; and tricarboxylic acid cycle. Acts upstream of or within homeostasis of number of cells within a tissue. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Nov 2024]

激活延胡索酸水合酶活性。参与多种过程，包括延胡索酸代谢过程；寒冷诱导的产热作用的正向调控；以及三羧酸循环。在组织细胞数量稳态的上游或内部发挥作用。位于线粒体中。在细胞器基质中活性。在多个结构中表达，包括消化系统；泌尿生殖系统；神经系统；呼吸系统；以及感觉器官。此基因的人类同源基因与延胡索酸缺乏症和肺非小细胞癌有关。与人类FH（延胡索酸水合酶）同源。[由基因组资源联盟提供，2024年11月]

搜集汇总

背景与挑战

背景概述

Fh1数据集描述了该基因的功能、作用机制和表达位置，显示其参与延胡索酸代谢和三羧酸循环等过程，位于线粒体并在多个生物系统中表达。该基因与人类FH基因同源，与延胡索酸酶缺乏症和非小细胞肺癌等疾病相关。