conditional FDR summary statistics for cranial vault shape

Summary statistics for conditional FDR-based GWAS of cranial vault shape.The original cranial vault shape GWAS (n = 6772) was obtained from<br>Goovaerts, S. et al. Joint multi-ancestry and admixed GWAS reveals the complex genetics behind human cranial vault shape. Nat Commun 14, 7436 (2023).<br>FDR statistics were obtained by applying the conditional FDR method introduced in<br>Andreassen, O. A. et al. Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLOS Genetics 9, e1003455 (2013).<br>We used facial shape, brain shape, and heel bone mineral density GWAS summary statistics in the conditional FDR analysis. These data are available from<br>https://www.ebi.ac.uk/gwas/studies/GCST90007181https://www.ebi.ac.uk/gwas/studies/GCST90012880<br>https://www.ebi.ac.uk/gwas/studies/GCST006979<br>

针对颅穹窿形态的基于条件错误发现率（conditional FDR）的全基因组关联研究（Genome-Wide Association Study, GWAS）汇总统计量。本项研究的原始颅穹窿形态全基因组关联研究（样本量n=6772）源自以下文献：Goovaerts S 等。《联合多祖先与混血人群GWAS揭示人类颅穹窿形态的复杂遗传基础》，发表于《自然-通讯》（*Nature Communications*）14卷，7436（2023年）。
条件错误发现率统计量通过应用Andreassen O A 等人提出的多效性信息条件错误发现率方法计算得到，该方法见于文献：《利用多效性信息条件错误发现率改进与精神分裂症和双相情感障碍相关的常见变异检测》，发表于《公共科学图书馆-遗传学》（*PLOS Genetics*）9卷，e1003455（2013年）。
本研究在条件错误发现率分析中，纳入了面部形态、脑形态及跟骨骨密度的全基因组关联研究汇总统计量。相关数据可从以下链接获取：
https://www.ebi.ac.uk/gwas/studies/GCST90007181
https://www.ebi.ac.uk/gwas/studies/GCST90012880
https://www.ebi.ac.uk/gwas/studies/GCST006979