Dataset for Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation

Astronauts embarking on deep space missions are at high risk of long-term
exposure to low doses of high linear energy transfer (LET) radiation,
which can contribute to the development of cancer and multiple
degenerative diseases. However, long term effects of exposure to low doses
of high LET radiation in plasma metabolite profiles have not been
elucidated. We utilized an untargeted metabolomics and lipidomics approach
to analyze plasma obtained from adult male Long Evans rats to determine
the longitudinal effects of low-dose proton and low-dose oxygen ion
whole-body irradiation on metabolic pathways. Our findings reveal that
radiation exposure induced modest changes in the metabolic profiles in
plasma, 7 months after exposure. Furthermore, we identified some common
metabolite dysregulations between protons and oxygen ions, which may
indicate a similar mechanism of action for both radiation types.

执行深空探测任务的宇航员长期暴露于低剂量高线性能量传递（linear energy transfer, LET）辐射的风险极高，此类辐射可诱发癌症及多种退行性疾病。然而，目前尚未阐明低剂量高LET辐射暴露对血浆代谢物谱的长期影响。本研究采用非靶向代谢组学与脂质组学方法，分析成年雄性Long Evans大鼠的血浆样本，以探究低剂量质子与低剂量氧离子全身照射对代谢通路的长期影响。研究结果显示，照射后7个月，辐射暴露可引起血浆代谢谱出现轻度改变。此外，本研究还发现质子与氧离子辐射存在共通的代谢物失调现象，这提示两类辐射可能具有相似的作用机制。