Pelvic floor muscle response after simulated birth injury and mechanisms of a skeletal muscle-derived ECM hydrogel (SKM)

Time course of pelvic floor muscles response was investigated, together with the efficacy of an ECM hydrogel therapy. A custom codeset panel to investigate pathways known to regulate appendicular muscles’ response to injury: immune response, myogenesis, muscle anabolism and catabolism, ECM remodeling, neovascularization, and neuromuscular junction development and maturation

本数据集针对盆底肌应答的时间进程与细胞外基质（Extracellular Matrix，ECM）水凝胶疗法的疗效展开探究，同时采用定制化基因集检测面板，对已知调控四肢肌损伤应答的信号通路进行分析，涵盖免疫应答、肌发生（myogenesis）、肌肉合成代谢与分解代谢、细胞外基质重塑、新生血管形成以及神经肌肉接头（neuromuscular junction）发育与成熟过程。