Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences

Altered Transcriptomic Profiles in Sex, Strain, ATG-treatment and Hyperoxia Exposure There has been a heighted interest in understanding the influences of sex and strain on variety of diseases states. We assessed the metabolomics profiles of male and female C57B6/J as well as male and female C3H/HeN. We pretreated each of these mice groups with 25mg/kg of Aurothioglucose (ATG) prior to being exposed to either 100% filtered air, or >95% oxygen for 96 hours. These studies begin to address the underlying altered metabolomic signaling that is influenced by sex and/or strain.

性别、品系、ATG处理与高氧暴露下的转录组谱（transcriptomic profiles）改变
学界对于探究性别与品系对多种疾病状态的影响已有浓厚研究兴趣。本研究检测了雄性与雌性C57B6/J、C3H/HeN小鼠的代谢组谱（metabolomic profiles）。所有小鼠组别均先以25mg/kg剂量的金硫葡萄糖（Aurothioglucose, ATG）进行预处理，随后分别暴露于100%过滤空气或体积分数>95%的氧气环境中，持续时长96小时。本系列研究旨在阐明受性别和/或品系影响的异常代谢组信号通路的潜在机制。