Systematic probe selection for brain-derived neurotrophic factor and trafficking related genes in the Allen Human Brain Atlas

This dataset consists of multiple files provided as Excel spreadsheets and a Python script. The primary dataset includes probe-level expression data retrieved from the Allen Human Brain Atlas for eight genes (BDNF, carboxypeptidase E (CPE), sortilin (SORT), huntingtin-associated protein 1 (HAP1), huntingtin (HTT), secretogranin II (SG2), and Arf1), with each row corresponding to an individual microarray probe. This file includes probe identification numbers, mean expression across brain regions, and standard deviation. The second Excel spreadsheet links probe expression data to donor-level metadata and brain region. In addition to the Excel spreadsheets, our dataset also includes a Python script that generates violin plots that allow for the visualization of each probe’s expression pattern across brain regions and across donors.

本数据集包含多个Excel电子表格文件与一段Python脚本。核心数据集为从艾伦人脑图谱（Allen Human Brain Atlas）中获取的8个基因的探针级表达数据，涉及的基因包括脑源性神经营养因子（BDNF）、羧肽酶E（CPE）、分选蛋白（SORT）、亨廷顿蛋白相关蛋白1（HAP1）、亨廷顿蛋白（HTT）、分泌粒蛋白II（SG2）以及Arf1，每一行对应一个独立的微阵列探针（microarray probe）。该文件包含探针编号、各脑区域平均表达量以及标准差。第二个Excel电子表格用于将探针表达数据与供体级元数据（metadata）及脑区域进行关联。除上述Excel电子表格外，本数据集还附带一段Python脚本，可生成小提琴图（violin plot），用于可视化各探针在不同脑区域以及不同供体间的表达模式。