Replication Data for: Electrical Fields Induced Inside the Rat Brain with Skin, Skull, and Dural Placements of the Current Injection Electrode

Transcranial electrical stimulation (tES) is rapidly becoming an indispensable clinical tool with its different forms. Animal data are crucially needed for better understanding of the underlying mechanisms of tES. For reproducibility of results in animal experiments, the electric fields (E-Fields) inside the brain parenchyma induced by the injected currents need to be predicted accurately. In this study, we measured the electrical fields in the rat brain perpendicular to the brain surface, i.e. vertical electric field (VE-field), when the stimulation electrode was placed over the skin, skull, or dura mater through a craniotomy hole.

经颅电刺激（Transcranial electrical stimulation, tES）凭借其多样的应用形式，正快速成为不可或缺的临床工具。为深入阐释经颅电刺激的潜在作用机制，动物实验数据至关重要。若要保障动物实验结果的可重复性，需精准预测刺激电流所诱导的脑实质内电场（Electric Fields, E-Fields）。本研究中，当刺激电极通过颅骨钻孔孔道分别置于皮肤、颅骨或硬脑膜上方时，我们测量了大鼠脑内垂直于脑表面的电场，即垂直电场（Vertical Electric Field, VE-field）。