Data S1 - Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs

Data for supporting figures. Hair cell counts: Number of hair cells in the inner sensory region of individual animals. This data was used to generate Figure 1. Hair cell expression: Number of GFP-positive cells co-expressing hair cell markers. This data was used to generate Figure 2. CtBP2 expression: Number of CtBP2 puncta per myosinVIIa-positive cell. This data was used to generate Figure 4. Peripheral fibres: Area of neurofilament-positive pixels within 10 mm of GFP-positive cells. This data was used to generate Figure 6. ABRs: Hearing thresholds of each animal pre-deafening, post-deafening and pre-perfusion. This data was used to generate Figure 7. SGN density: Density of spiral ganglion neurons in the basal, middle and apical turns of the cochleae of all animals. This data was used in the “Auditory Neuron Densities” section of the results.
(XLSX)

用于支撑实验图表的数据集：
毛细胞计数（Hair cell counts）：单个动物内耳感觉区域内的毛细胞数量。本数据用于生成图1。
毛细胞表达量（Hair cell expression）：共表达毛细胞标志物的绿色荧光蛋白（Green Fluorescent Protein, GFP）阳性细胞数量。本数据用于生成图2。
CtBP2表达量（CtBP2 expression）：每个肌球蛋白VIIa（myosin VIIa）阳性细胞内的CtBP2斑点数量。本数据用于生成图4。
外周神经纤维（Peripheral fibres）：GFP阳性细胞周边10 mm范围内的神经丝阳性像素区域面积。本数据用于生成图6。
听性脑干反应（Auditory Brainstem Response, ABRs）：每只动物在致聋前、致聋后及灌注前的听力阈值。本数据用于生成图7。
螺旋神经节神经元密度（Spiral Ganglion Neuron Density, SGN density）：所有动物耳蜗底转、中转及顶转区域的螺旋神经节神经元密度。本数据用于结果部分的「听觉神经元密度」章节。
本数据集为XLSX格式。