Are the blood pressure levels associated with the hippocampal, temporal and amygdala volumes in sedentary females? A sub-group analysis of a cross-sectional study

This study investigated the impact of sedentary behavior and hypertension on brain size, focusing on the female population, with a retrospective analysis of MRI data from 19 sedentary females. The results revealed a significant relationship between hypertension and brain structure changes, particularly an enlargement of the hippocampal region in hypertensive females, which was most pronounced in early stages of hypertension but less pronounced in more advanced stages. These findings underscore the importance of monitoring hypertension, as it can silently affect cognitive health, emphasizing the need for early detection and management to prevent cognitive decline in individuals with sedentary lifestyles, especially females. Further research is needed to understand the underlying mechanisms and clinical implications of these cerebral alterations.

本研究针对女性人群，通过回顾性分析19名久坐女性的磁共振成像（MRI）数据，探究了久坐行为与高血压对脑体积的影响。研究结果显示，高血压与脑结构变化存在显著关联；具体而言，高血压女性的海马体区域出现体积增大，且该现象在高血压早期最为显著，病程进展至后期时则逐渐减弱。上述研究结果凸显了监测高血压的重要性——该疾病可在无形中影响认知健康，同时强调了针对久坐人群（尤其是女性）开展早期检测与干预的必要性，以预防其认知功能衰退。未来仍需开展进一步研究，以阐明此类脑部结构变化的潜在机制与临床意义。