Pd-Catalyzed Cyclization and Carbene Migratory Insertion: New Approach to 3‑Vinylindoles and 3‑Vinylbenzofurans

A Pd-catalyzed stereoselective synthesis of 3-vinylindoles and 3-vinylbenzofurans has been developed. The reaction merges the alkyne-based Pd-catalyzed cyclization and Pd carbene migratory insertion in a single catalytic cycle, generating a C–C single bond and a CC double bond in one operation.

本研究开发了一种钯（Pd）催化的立体选择性合成方法，可用于制备3-乙烯基吲哚（3-vinylindoles）与3-乙烯基苯并呋喃（3-vinylbenzofurans）。该反应将基于炔烃的钯催化环化过程与钯卡宾迁移插入步骤整合至单一催化循环中，通过一步操作同时构建碳-碳单键与碳-碳双键。