Ileal bacterial microbiome of mice deficient in NADPH oxidases NOX1 and NOX4

NOX1 and NOX4 derived reactive oxygen species communicate with ileal microbiota. The project investigated changes in the bacterial and fungal microbiota of the ileum of male NOX1-/y (NOX1 KO) , NOX4-/- (NOX4 KO) and NOX1-/y NOX4 -/- (NOX1 KO NOX4 KO) mice and male internal control WT mice (F3 generation) at age 16 weeks.

烟酰胺腺嘌呤二核苷酸磷酸氧化酶1（NOX1）与烟酰胺腺嘌呤二核苷酸磷酸氧化酶4（NOX4）介导产生的活性氧（reactive oxygen species）可与回肠微生物群进行信号互作。本项目针对16周龄雄性NOX1基因敲除（NOX1-/y，NOX1 KO）、NOX4基因敲除（NOX4-/-，NOX4 KO）、NOX1与NOX4双基因敲除（NOX1-/y NOX4-/-，NOX1 KO NOX4 KO）小鼠，以及作为内部对照的雄性F3代野生型（WT）小鼠的回肠细菌与真菌微生物群变化展开了研究。