Exon-level expression profiling of normal colonic mucosa samples.

These samples have been analyzed for global alternative splicing variation on exon-level expression data using the FIRMA algorithm. We have identified and described transcriptome instability as a genome-wide, pre-mRNA splicing related characteristic of solid cancers. This Series consists of 19 normal colonic mucosa samples from colorectal cancer patients, and is an amendment to a larger series of colorectal cancer and adjacent normal colonic mucosa samples analyzed for gene expression at the exon-level (GSE24550).

本数据集样本基于外显子水平表达数据，采用FIRMA算法（FIRMA algorithm）完成了全局性可变剪接变异分析。本研究已鉴定并阐明，转录组不稳定性是实体瘤全基因组范围内与前信使RNA（pre-mRNA）剪接相关的特征。本数据集系列包含19例结直肠癌患者来源的正常结肠黏膜样本，是针对更大规模结直肠癌及其邻近正常结肠黏膜样本（外显子水平基因表达分析，编号GSE24550）的补充数据集。