Transcriptional profiling of lung cancer cell expressing MET wt and its variant

Lung cancer cells expressing polymorphic MET-N375S demonstrated enhanced oncogenic phenotype. The transcriptional profile of isogenic lung cancer cells overexpressing each MET isoform were compared to elucidate mechanisms leading to the observed phenotype. RNAseq analyses of H2170 cells overexpressing METwt and MET-N375S variant.

表达多态性MET-N375S的肺癌细胞表现出增强的致瘤表型。为阐明该观测表型的潜在分子机制，研究人员对过表达各MET亚型的同基因肺癌细胞的转录组谱开展了对比分析，并针对过表达野生型MET（METwt）与MET-N375S变体的H2170细胞完成了RNA测序（RNAseq）分析。