Wnt Signaling Mediates Oncogenic Synergy Between Akt and Dlx5 in T-Cell Lymphomagenesis by Enhancing Cholesterol Synthesis [TCF ChIP]

Akt2;Dlx5 double transgenic mice develops T-ALL, and these cells have up regulated Cholesterol synthesis via Wnt pathway for survival ChIP-seq

Akt2与Dlx5双转基因小鼠（double transgenic mice）可诱发T细胞急性淋巴细胞白血病（T-ALL），该疾病的肿瘤细胞可通过Wnt信号通路（Wnt pathway）上调胆固醇合成以维持存活，本数据集为对应研究的染色质免疫共沉淀测序（ChIP-seq）数据。