Dati medico_sanitari_completi(1).sav

Anticholinergic Burden in adult and elderly people with Intellectual Disabilities.The 2012 updated version of the Anticholinergic Burden Score (ACB) was calculated for a multicentre sample of 276 adult and older people over 40 years with ID
and associations with factors assessed. Antipsychotics, antiepileptics, anxiolytics, and antidepressants were
the most frequent classes contributing to the total ACB score. Residential care setting was associated with higher exposure (ACB score 3+), both community housing (OR 4.63, 95%CI 1.08 - 19.95) and nursing home facility (OR 9.99, 2.32 - 43.04) as were a mental health (OR 25.56, 95% CI 8.08 - 80.89) and a neurological (OR 4.14, 1.32 - 12.94) condition. Age and gender were not significant nor were the other clinical conditions (somatic comorbidity, level and typology of ID). Higher anticholinergic load was significantly more frequent in laxative users (22.6% ACB3+ vs. 5.1% ACB 0)
(p=0.003).

成人与老年智力障碍（Intellectual Disabilities）人群的抗胆碱能负荷。本研究针对276名40岁以上的成年及老年智力障碍多中心样本，计算了2012年更新版抗胆碱能负荷评分（Anticholinergic Burden Score, ACB），并分析其与各项评估因素的关联。抗精神病药、抗癫痫药、抗焦虑药与抗抑郁药是贡献于总ACB评分的最常见药物类别。居住环境与更高的抗胆碱能暴露（ACB评分≥3）相关：社区住宅（比值比（Odds Ratio, OR）4.63，95%置信区间（Confidence Interval, CI）1.08~19.95）与护理院机构（OR 9.99，2.32~43.04）均呈现此关联；精神疾病（OR 25.56，95%CI 8.08~80.89）与神经系统疾病（OR 4.14，1.32~12.94）同样与高ACB评分相关。年龄与性别未呈现显著统计学关联，其余临床因素（躯体共病、智力障碍的严重程度与分型）亦无显著相关性。使用泻药的人群中，高抗胆碱能负荷（ACB3+）的占比显著更高（22.6% vs. 5.1%，ACB0），差异具有统计学意义（p=0.003）。