Kinome expression profiling of muscle invasive bladder cancer (MIBC) patients. Kinome expression profiling of muscle invasive bladder cancer (MIBC) patients

Muscle invasive bladder cancer (MIBC) is one of the aggressive cancer with limited treatment options. Targeted gene expression profiling in normal and tumor samples from MIBC patients could aid in identification of potential therapeutic targets. Thus we used kinase specific panel to study their expression pattern and to identify targetable genes. Overall design: Tumor and adjacent normal macrodissected tissues were obtained from 24 MIBC patients. RNA isolated from tissues were profiled on the nCounter Human Kinase Panel.

肌层浸润性膀胱癌（MIBC）是一类侵袭性强且治疗选择有限的恶性肿瘤。对MIBC患者的正常组织与肿瘤样本开展靶向基因表达谱分析，有助于识别潜在治疗靶点。为此，本研究借助激酶特异性检测面板，分析相关基因的表达模式并筛选可靶向治疗的基因。实验设计概述：本研究从24名MIBC患者体内获取了肿瘤组织及大体分离的癌旁正常组织；从上述组织中提取的RNA，通过nCounter Human Kinase Panel完成表达谱检测。