ChIP-seq of MLL3 Delta mice liver and wild-type littermate controls

We investigated the in vivo role of MLL3-dependent methylation of histone 3 lysine 4 at zeitgeber time 18, by performing H3K4me1 and H3K4me3 ChIP-seq in mouse liver, from MLL3 Delta mice and littermate wild-type controls.本研究探究了授时时间18（zeitgeber time 18）下MLL3依赖的组蛋白H3赖氨酸4甲基化的体内功能，实验通过对MLL3缺失型（MLL3Δ）小鼠及其同窝野生型对照小鼠的肝脏组织，开展组蛋白H3第4位赖氨酸单甲基化（H3K4me1）与组蛋白H3第4位赖氨酸三甲基化（H3K4me3）染色质免疫共沉淀测序（ChIP-seq）完成。