Distinct Long Non-coding RNA Regulatory Architectures Encode Lineage Stability and Epithelial Plasticity

Filename Scientific content Status lncrna_lineage_hematopoietic_pc1.csv 1,410 probe sets driving PC1 (haematopoietic axis). Ranked by |PCA loading|. Loading range: +0.005563 to +0.005774. Shannon entropy: 10.4614 bits. All positive loadings are on the haematopoietic-enriched axis. ✓ Ready lncrna_lineage_brain_pc2.csv 1,410 probe sets driving PC2 (brain/neural axis). Loading range: +0.007709 to +0.010418. Shannon entropy: 10.4589 bits. Mixed probe types: TC=1,041, PSR=289, JUC=7. ✓ Ready lncrna_lineage_breast_pc3.csv 1,410 probe sets driving the PC3 positive pole (breast epithelial axis). Loading range: +0.009501 to +0.013979. Shannon entropy: 10.4570 bits. Widest |loading| range of all four lineages. ✓ Ready lncrna_lineage_endometrium_pc3.csv 1,410 probe sets driving the PC3 negative pole (endometrial axis). Loading range: −0.010876 to −0.005712. Shannon entropy: 10.4503 bits. Negative loadings = endometrium occupies opposite PC3 pole to breast. ✓ Ready summary_statistics.csv Aggregate statistics for all 4 lineages: loading ranges, means, SD, Shannon entropy, and probe-type counts. Machine-readable summary used for Table 1 / Results paragraph. ✓ Ready overlap_matrix.csv 4×4 pairwise intersection matrix. Confirms Brain∩Endometrium=33, all other pairwise=0, and all four=0. Direct evidence for lineage-specificity of regulatory programmes. ✓ Ready brain_endometrium_shared_probes.csv Complete listing of all 33 probe sets shared between Brain (PC2) and Endometrium (PC3), with PC2 loading, PC3 loading, and rank in each list. ✓ Ready README.txt Plain-text description of the entire dataset. Zenodo displays this as the record description. Contains column definitions, method notes, LncExpDB annotation status, source dataset accessions, and citation blocks. ✓ Ready ℹ️ The ENST_transcript_id, RefSeq_accession, gene_symbol, and lncexpdb_validated columns in the four lineage CSV files are currently blank. This is correctly noted in the README.txt. You can update the Zenodo record with annotated versions after completing the LncExpDB lookup step — Zenodo supports versioned updates without losing the DOI.文件名 | 科学内容 | 状态 lncrna_lineage_hematopoietic_pc1.csv 1,410个驱动主成分分析1（PC1，造血轴）的探针集（probe sets）。按|PCA加载值|排序。加载值范围：+0.005563 至 +0.005774。香农熵（Shannon entropy）：10.4614 比特。所有正加载值均位于造血富集轴上。 ✓ 已就绪 lncrna_lineage_brain_pc2.csv 1,410个驱动主成分分析2（PC2，脑/神经轴）的探针集。加载值范围：+0.007709 至 +0.010418。香农熵：10.4589 比特。混合探针类型：TC=1,041、PSR=289、JUC=7。 ✓ 已就绪 lncrna_lineage_breast_pc3.csv 1,410个驱动主成分分析3（PC3）正极（乳腺上皮轴）的探针集。加载值范围：+0.009501 至 +0.013979。香农熵：10.4570 比特。为四个谱系中|加载值|范围最广的数据集。 ✓ 已就绪 lncrna_lineage_endometrium_pc3.csv 1,410个驱动主成分分析3（PC3）负极（子宫内膜轴）的探针集。加载值范围：−0.010876 至 −0.005712。香农熵：10.4503 比特。负加载值对应的子宫内膜占据PC3轴上与乳腺上皮相反的极位。 ✓ 已就绪 summary_statistics.csv 包含四个谱系的汇总统计数据：加载值范围、均值、标准差（Standard Deviation, SD）、香农熵及探针类型计数。为可机器读取的汇总文件，用于表1及结果段落的撰写。 ✓ 已就绪 overlap_matrix.csv 4×4的两两交集矩阵。验证结果显示：脑谱系与子宫内膜谱系的交集探针集数为33，其余所有两两组合交集均为0，四者共同交集亦为0。该结果直接证明调控程序具有谱系特异性。 ✓ 已就绪 brain_endometrium_shared_probes.csv 收录脑谱系（PC2）与子宫内膜谱系（PC3）间共享的全部33个探针集，包含各探针集的PC2加载值、PC3加载值及其在各自列表中的排名。 ✓ 已就绪 README.txt 本数据集的纯文本说明文件，在Zenodo平台上作为数据集记录描述展示。内容包含列定义、方法说明、LncExpDB注释状态、源数据集登录号及引用区块。 ✓ 已就绪 ℹ️ 四个谱系CSV文件中的ENST转录本ID（ENST_transcript_id）、RefSeq登录号（RefSeq_accession）、基因符号（gene_symbol）及LncExpDB验证列（lncexpdb_validated）目前均为空值，该信息已在README.txt中注明。完成LncExpDB注释步骤后，您可对Zenodo记录进行带版本号的更新（不会丢失DOI），Zenodo支持此类无DOI丢失风险的版本化更新操作。