Identification and validation of the shared pathways and common biomarker in diabetes and osteoarthritis

Epidemiological studies suggest a potential link between osteoarthritis (OA) and diabetes mellitus (DM) despite unclear molecular mechanisms.A greater understanding of the mechanisms that link OA and DM is needed to identify therapeutic targets in diabetic individuals who develop OA.In our study, we found 142 genes that are affected by both diseases. PTEN and GATA3 are excellent diagnostic markers for both OA and DM.With increasing glucose levels, PTEN expression increased and GATA3 expression decreased in chondrocytes.The provided data consists of article images that are associated with the original dataset.

流行病学研究表明，尽管分子机制尚未明确，但骨关节炎（Osteoarthritis, OA）与糖尿病（Diabetes Mellitus, DM）之间存在潜在关联。为了在罹患骨关节炎的糖尿病患者中确定治疗靶点，我们需要更深入地解析二者之间的关联机制。本研究中，我们鉴定出142个同时受两种疾病调控的基因。磷酸酶与张力蛋白同源物（PTEN）以及GATA结合蛋白3（GATA3）可作为骨关节炎与糖尿病的优质诊断标志物。随着葡萄糖水平升高，软骨细胞内的PTEN表达水平上调，而GATA3表达水平下调。本次提供的数据包含与原始数据集相关联的论文图片。