Retinoic acid Signaling

Retinoic Acid (RA) promotes neurogenesis by regulating the switch between proliferation and differentiation. RA binds to retinoic acid receptors (e.g. RARA, RARB and RARG) which in turn bind and activate coreceptor RXRA. RXRA downstream effects include inhibition of proliferation, inhibition of NOTCH and the restoring of expression of neurogenic genes such as NEUROG1 and NEUROG2.

视黄酸（Retinoic Acid, RA）通过调控细胞增殖与分化之间的转换来促进神经发生。视黄酸可结合视黄酸受体（retinoic acid receptors，如RARA、RARB及RARG），该类受体进而结合并激活共受体RXRA。RXRA所介导的下游效应包括增殖抑制、NOTCH抑制，以及恢复NEUROG1、NEUROG2等神经发生相关基因的表达。