Severity of lung function impairment drives transcriptional phenotypes of COPD and relates to immune and metabolic processes

Gene expression profiles were generated from induced sputum samples in COPD and healthy controls. The study identified transcriptional phenotypes of COPD. This study used unsupervised hierarchical clustering of induced sputum gene expression profiles of 72 stable COPD patients and 15 healthy controls to identify distinct and clinically relevant transcriptional COPD phenotypes.

本研究从慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Disease, COPD）患者及健康对照者的诱导痰样本中构建了基因表达谱。本研究鉴定出了COPD的转录表型。本研究通过对72例稳定期COPD患者与15例健康对照者的诱导痰基因表达谱开展无监督层次聚类分析，以此鉴定出特征鲜明且具有临床相关性的COPD转录表型。