fMRI/fPACT 3D image stacks and analysis codes for function

Functional human brain imaging is mainly based on
blood-oxygen-level-dependent (BOLD) functional magnetic resonance
imaging (fMRI), which is a mature technology with recognized constraints
in certain clinical and research applications. Photoacoustic computed
tomography (PACT) is a promising complementary modality to fMRI as it does
not involve magnetic fields and allows quantification of deoxyhemoglobin
and oxyhemoglobin concentrations, convertible to oxygen saturation and
blood volume. Here, we demonstrate PACT of the human brain. 3D
functional image stacks of fMRI and PACT as well as the customized
codes for functional analysis are included.
'Data/fMRI data/' includes the image stacks of fMRI
acquisition. The fMRI brain function can be extracted by loading the
parameter scripts in 'Data/fMRI script/' into
SPM12. 'Data/fPACT data/' includes the image stacks of
PACT acquisition. The PACT brain function can be
extracted by
running 'Code/fPACT script/run_function_recon.m'.

功能性人脑成像主要基于血氧水平依赖（blood-oxygen-level-dependent，BOLD）功能磁共振成像（functional magnetic resonance imaging，fMRI），该技术已较为成熟，但在部分临床与科研应用中存在公认的局限性。光声计算机断层扫描（photoacoustic computed tomography，PACT）是一种极具应用前景的fMRI互补成像模态，其无需依赖强磁场，可实现脱氧血红蛋白与氧合血红蛋白浓度的定量检测，相关结果可进一步转换为血氧饱和度与血容量参数。本研究成功实现了人脑PACT成像。本数据集包含fMRI与PACT的三维功能图像序列，以及用于功能分析的定制化代码。'Data/fMRI data/' 文件夹存储了fMRI采集得到的图像序列，将'Data/fMRI script/'路径下的参数脚本导入SPM12即可提取fMRI脑功能信号。'Data/fPACT data/' 文件夹存储了PACT采集得到的图像序列，运行'Code/fPACT script/run_function_recon.m'脚本即可提取PACT脑功能信号。