Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli硫内酯霉素（thiolactomycin）5位的构效关系（Structure-activity relationships）研究表明：完整的5(R)-异戊二烯单元是其针对结核分枝杆菌（Mycobacterium tuberculosis）与大肠杆菌（Escherichia coli）来源的缩合酶产生活性所必需的。