Alteration of gene expression in E11.5 XY Cdyl deficient gonadal somatic cells

Cdyl deficient mice exhibited partial sex reversal. To determine this cause, RNA-seq was used to identify genes with altered expression in Cdyl deficient gonads. Comparative gene expression profiling analysis of RNA-seq data for Cdyl hetero deficient gonads and Cdyl homo deficient gonads

Cdyl缺陷小鼠表现出部分性反转现象。为探明其潜在成因，本研究采用RNA测序（RNA-seq）技术，在Cdyl缺陷性腺中筛选表达发生改变的基因，并对Cdyl杂合缺陷性腺与Cdyl纯合缺陷性腺的RNA-seq数据开展比较基因表达谱分析。