Rosa-Garrido M et al.pdf

Our findings provide a high-resolution chromatin architecture resource for cardiac epigenomic investigations and demonstrate that global structural remodeling of chromatin underpins heart failure. The newly identified principles of endogenous chromatin structure have key implications for epigenetic therapy.

本研究成果为心脏表观基因组学研究提供了高分辨率染色质架构（chromatin architecture）资源，并证实染色质全局结构重塑是心力衰竭发生发展的核心病理基础。新发现的内源性染色质架构调控原则，对表观遗传治疗具有重要指导意义。