Decreased Ovarian Reserve Predicts Inexplicability of Recurrent Miscarriage? A Retrospective Analysis

ObjectiveTo evaluate anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and female age in women with recurrent miscarriage and to compare women with explained and idiopathic recurrent miscarriage.DesignRetrospective cohort study.SettingUniversity hospital, tertiary care center.PatientsWomen with recurrent miscarriage (78 explained, 66 idiopathic).Intervention(s)None.Main Outcome Measures(s)Anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and age.ResultsAnti-Mullerian hormone and estradiol were significantly lower in women with idiopathic recurrent miscarriage (median 1.2 ng/ml, IQR 0.6–2.1, and median 36.5 pg/ml, IQR 25.8–47.3, respectively) than in women with explained recurrent miscarriage (median 2.0 ng/ml, IQR 1.1–2.7, and median 42.5 pg/ml, IQR 32.8–59.8, respectively; pConclusionIdiopathic recurrent miscarriage was associated with lower basal estradiol and anti-Mullerian hormone levels compared to explained recurrent miscarriage.