Decreased Ovarian Reserve Predicts Inexplicability of Recurrent Miscarriage? A Retrospective Analysis

ObjectiveTo evaluate anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and female age in women with recurrent miscarriage and to compare women with explained and idiopathic recurrent miscarriage.DesignRetrospective cohort study.SettingUniversity hospital, tertiary care center.PatientsWomen with recurrent miscarriage (78 explained, 66 idiopathic).Intervention(s)None.Main Outcome Measures(s)Anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and age.ResultsAnti-Mullerian hormone and estradiol were significantly lower in women with idiopathic recurrent miscarriage (median 1.2 ng/ml, IQR 0.6–2.1, and median 36.5 pg/ml, IQR 25.8–47.3, respectively) than in women with explained recurrent miscarriage (median 2.0 ng/ml, IQR 1.1–2.7, and median 42.5 pg/ml, IQR 32.8–59.8, respectively; pConclusionIdiopathic recurrent miscarriage was associated with lower basal estradiol and anti-Mullerian hormone levels compared to explained recurrent miscarriage.目的 评估复发性流产女性的抗缪勒管激素（anti-Mullerian hormone）、基础卵泡刺激素、黄体生成素、雌二醇水平及年龄，并对比病因明确复发性流产（explained recurrent miscarriage）与特发性复发性流产（idiopathic recurrent miscarriage）患者的上述指标差异。 研究设计 回顾性队列研究。 研究地点 三级医疗中心大学附属医院。 研究对象 复发性流产女性共144例，其中病因明确复发性流产78例，特发性复发性流产66例。 干预措施 无。 主要结局指标 抗缪勒管激素、基础卵泡刺激素、黄体生成素、雌二醇水平及年龄。 结果 特发性复发性流产患者的抗缪勒管激素及雌二醇水平显著低于病因明确复发性流产患者：前者抗缪勒管激素中位数为1.2 ng/ml，四分位间距（IQR）0.6~2.1，雌二醇中位数为36.5 pg/ml，四分位间距25.8~47.3；后者抗缪勒管激素中位数为2.0 ng/ml，四分位间距1.1~2.7，雌二醇中位数为42.5 pg/ml，四分位间距32.8~59.8（差异具有统计学意义，原文P值未完整给出）。 结论 与病因明确复发性流产患者相比，特发性复发性流产患者的基础雌二醇及抗缪勒管激素水平更低。