Synthesis of Quinolones by Nickel-Catalyzed Cycloaddition via Elimination of Nitrile

Substituted quinolones were efficiently synthesized via the nickel-catalyzed cycloaddition of o-cyanophenylbenzamide derivatives with alkynes. The reaction involves elimination of a nitrile group by cleavage of the two independent aryl–cyano and aryl–carbonyl C–C bonds of the amides.

取代喹诺酮类化合物可通过镍催化邻氰基苯甲酰胺衍生物与炔烃的环加成反应高效合成。该反应通过断裂酰胺底物中两个独立的芳基-氰基与芳基-羰基C-C键，实现腈基的脱除。