Salivary microbiome analysis of severe early childhood caries

severe early childhood caries (SECC) is a bacterial inflammatory disease with complex pathology. Although changes in the oral microbiota and metabolic profile of patients with ECC have been identified, the salivary metabolites and the relationship of host-bacterial interactions with biochemical metabolism remain unclear. We aimed to analyse alterations in the salivary microbiome and metabolome of children with SECC as well as their correlations. Accordingly, we aimed to explore potential salivary biomarkers in order to gain further insight into the pathophysiology of dental caries.

重度儿童早期龋病（severe early childhood caries，SECC）是一种病理机制复杂的细菌性炎症性疾病。尽管学界已明确儿童早期龋病患者的口腔微生物群与代谢谱存在异常改变，但唾液代谢物特征以及宿主-细菌互作与生化代谢之间的关联仍未阐明。本研究旨在分析重度儿童早期龋病患儿的唾液微生物组与代谢组的变化特征及其相互关联。据此，本研究拟探索潜在的唾液生物标志物，以期进一步阐明龋病的病理生理机制。